Taking aspirin and ibuprofen together may increase the risk of side effects. The pain relievers aspirin and ibuprofen are both classed as NSAIDs and so have similar side effects. They can be Antibiotics. If you are taking methotrexate, you should completely avoid taking any antibiotic that contains trimethoprim-sulfa, such as Bactrim, Sulfatrim, and Septra. Adverse effects are caused by the antibiotic's ability to reduce methotrexate absorption in the body. When the absorption rate is slowed, it can lead to a buildup of the Applies to: Motrin (ibuprofen) and diclofenac. Using ibuprofen together with diclofenac is generally not recommended. Combining these medications may increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding, ulceration, and rarely, perforation. Gastrointestinal perforation is a potentially fatal condition 5. Nelfinavir. Nelfinavir (Viracept) is an antiviral medication that’s used to treat HIV. It’s less commonly prescribed than other HIV medications, but it’s still available for use. There’s not much data, but nelfinavir may increase the amount of azithromycin that your body absorbs into its bloodstream. Diclofenac is a medication used in the management and treatment of inflammatory conditions and pain. It is in the class of non-steroidal anti-inflammatory drugs (NSAID). This activity outlines the indications, mechanism of action, administration, adverse effect profile, contraindications, and other key factors for diclofenac in the clinical setting pertinent to healthcare team members to treat However, using non-steroidal anti-inflammatory drugs (NSAIDs) can reduce pain from arthritis by about 30%—the same amount of pain relief that people with arthritis get from opioids. Indocin and ibuprofen are two common NSAIDs that can be used to treat arthritis. Indocin is a brand name of the prescription NSAID indomethacin. NSAIDs and methylprednisolone can both be hard on the stomach. They can cause an upset stomach and nausea. In more severe cases, both medications raise the risk of stomach bleeding and ulcers. Taking them together can enhance these risks. If possible, try to avoid taking NSAIDs and methylprednisolone at the same time. Applies to: Aspirin Low Strength (aspirin) and diclofenac. Talk to your doctor before using aspirin together with diclofenac. Combining these medications may increase your risk of developing gastrointestinal ulcers and bleeding. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. 2y2ofqK.